116: Understanding Vorasidenib's Therapeutic Benefit on Neurocognition, Seizure Control in Diffuse Gliomas

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, Katherine Peters, PhD, a neurologist and neurooncologist at the Preston Robert Tisch Brain Tumor Center at Duke University provided context on a new analysis from the phase 3 INDIGO trial, a study assessing vorasidenib in patients with mutant isocitrate dehydrogenase (mIDH) 1/2 diffuse gliomas. The conversation, which occurred at the 2024 AAN Annual Meeting, covered the covered the therapeutic potential of this agent and its impacts on quality of life, neurocognition, and seizure control. Peters, an expert in the field, provided insight on the mechanism of action of vorasidenib, the added value behind the exploratory analysis, and the next steps in research. Furthermore, she provided context on the patient sample observed and why these data may hold significant weight going forward.  Looking for more neuromuscular discussion? Check out the NeurologyLive® epilepsy clinical focus page. Episode Breakdown: 1:05 – Mechanism of action of vorasidenib, a mIDH 1/2 inhibitor 2:00 – Overview of exploratory analysis results 4:20 – Significance of new data, how it adds to previous primary and secondary outcomes 5:50 – Neurology News Minute 8:25 – Next steps for the study and use of vorasidenib 10:35 – Remaining unmet needs for patients with diffuse gliomas The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Diazepam Buccal Film’s Role in Treating Intermittent Pediatric Seizures, with Michael Rogawski, MD, PhD Ocrelizumab Gains EU CHMP Positive Opinion for Subcutaneous Formulation to Treat MS FDA Approves Sprinkle Formulation of Neurocrine Biosciences’ Valbenazine for Tardive Dyskinesia or Huntington disease Chorea Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.